The term “medical condition” is very broad because it includes all diseases, illnesses, and disorders. Many people are well aware of the more common medical conditions like diabetes, asthma, and hypertension.  However, there are quite a few rare medical conditions that some doctors don’t even know exist. Since these conditions are so uncommon, it may take years for a patient to get properly diagnosed. As far as treatment goes, this could take even longer.  That is why it’s so important to put a spotlight on the top 25 Rarest Medical Conditions Ever Recorded. Sharing information about the symptoms will help these rare medical conditions become more widely recognized. Last Updated on December 24, 2019

Sleeping Beauty Syndrome

Sleeping Beauty
It’s quite normal to feel tired. In fact, the majority of people often feel tired throughout the day. The average person normally takes a 20-minute nap to help them rejuvenate. A person with sleeping beauty syndrome can sleep up to 20 hours a day and still feel tired. The rare disorder also causes a person to feel confused and groggy. Stimulant pills have been used as a way to help reduce sleepiness and promote a more active lifestyle.

Alexander Disease

Heart Beat
Scientists originally thought that Alexander disease typically occurred during the early stages of life. However, after further research, they concluded that a person can develop it at any age. Since Alexander disease is estimated to occur in one out of every million births, it may take years for a patient to get properly diagnosed. A few common symptoms include a thin scalp, lowered heartbeat, headaches, and vomiting.


Eating another human being seems like a completely barbaric, unnatural thing to do. However, there are communities in New Guinea that participate in a form of cannibalism as part of a funeral ritual. Scientists have found that the people who consumed contaminated human brain tissue contract the Kuru disease. This extremely rare medical condition attacks part of the brain responsible for coordination and balance.

Moebius Syndrome

A person’s face is perhaps one of the most important parts of the body. It’s how most people communicate and it gives a person their outer identity. That is why researchers are trying to find a  treatment for Moebius syndrome. This rare neurological condition affects the muscles that control facial expression and eye movement. Infants with this condition tend to need a feeding tube in order to consume enough nutrition to survive. 


If one parent passes on to their child a specific abnormal gene, that child will get Porphyria. This rare condition is basically a group of disorders created by a buildup of natural chemicals in the body. Some symptoms may include abdominal pain, diarrhea, vomiting, and hallucinations. Luckily, there is a treatment and it involves intravenous infusions. Scientists are also researching a possible drug version treatment option.
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